65085-83-8Relevant articles and documents
Microwaves assisted synthesis of antitumor agents of novel azoles, azines, and azoloazines pendant to phenyl sulfone moiety and molecular docking for VEGFR-2 kinase
Abdulwahab, Hanan Gaber,Alsaedi, Amani M. R.,Farghaly, Thoraya A.,Shaaban, Mohamed R.
, (2021/10/21)
The present research article contains two valuable starting phenylsulfone-enaminones which were synthesized in short reaction time with excellent yield under microwaves irradiation. These two enaminones were reacted with both nucleophiles and electrophiles to afford novel heterocycles bearing phenylsulfone moiety. The structure of all prepared phenylsulfone derivatives as well as their mechanistic pathways were studied based on their spectral data. Moreover, seventeen phenylsulfone derivatives were screened in vitro for their anticancer activity against HepG-2 and HCT-116 cell lines. Compounds 4 and 7a were equipotent to doxorubicin against HepG-2 cell line. Moreover, diphenyl sulfone derivative 7a was 3-fold more potent than doxorubicin against human colon cancer cell line with IC50 = 3.13 and 9.4 μg/mL, respectively. Remarkably, compound 7b was 2-fold more active than doxorubicin against the two tested cell lines. A docking study of title compounds into VEGFR-2 kinase was also conducted.
Sulfoxide and Sulfone Synthesis via Electrochemical Oxidation of Sulfides
Lee, Sunwoo,Park, Jin Kyu
, p. 13790 - 13799 (2021/10/12)
The oxidation of diaryl sulfides and aryl alkyl sulfides to the corresponding sulfoxides and sulfones under electrochemical conditions is reported. Sulfoxides are selectively obtained in good yield under a constant current of 5 mA for 10 h in DMF, while sulfones are formed as the major product under a constant current of 10 or 20 mA for 10 h in MeOH. The oxygen of both the sulfoxide and sulfone function is derived from water.
Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis
Cui, Wenwen,Jiang, Min,Lv, Jian,Song, Xiuyan,Sun, Kai,Xu, Guiyun,Yan, Qiuli,Yang, Daoshan
, p. 3663 - 3668 (2021/05/31)
An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates is reported. In our protocol, a single ligand CuI photocatalyst formed in situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrates a promising approach toward the synthesis of diverse and useful organosulfones.
