321438-45-3Relevant academic research and scientific papers
From sequencamers to foldamers? Tetrameric furanose carbopeptoids from cis- and trans-5-aminomethyl-tetrahydrofuran-2-carboxylates
Long, Daniel D.,Hungerford, Natasha L.,Smith, Martin D.,Brittain, Dominic E. A.,Marquess, Daniel G.,Claridge, Timothy D. W.,Fleet, George W. J.
, p. 2195 - 2198 (1999)
The synthesis of three stereoisomeric cis- and trans-5-azidomethyl- tetrahydrofuran-2-carboxylates in which a ketal-protected cis-diol unit is present is described. The monomers undergo efficient oligomerisation to tetrameric carbopeptoids in which the diol protection facilitates ready purification by chromatography which augurs well for the formation of homogeneous higher polymers.
Tetrahydrofuran amino acids: Secondary structure in tetrameric and octameric carbopeptoids derived from a D-allo 5-(aminomethyl)-tetrahydrofuran-2-carboxylic acid
Hungerford, Natasha L.,Claridge, Timothy D.W.,Watterson, Mark P.,Aplin, Robin T.,Moreno, Andres,Fleet, George W.J.
, p. 3666 - 3679 (2007/10/03)
The synthesis of a D-allo-5-(azidomethyl)tetrahydrofuran-2-carboxylate as an amino acid precursor (in which the carboxylic acid is cis to the azidomethyl substituent and trans to the diol moiety) is reported from D-ribose. The oligomerisation of this mono
