32150-13-3Relevant articles and documents
Carbene-catalyzed desymmetrization of 1,3-diols: Access to optically enriched tertiary alkyl chlorides
Li, Bao-Sheng,Wang, Yuhuang,Proctor, Rupert S. J.,Jin, Zhichao,Chi, Yonggui Robin
supporting information, p. 8313 - 8316 (2016/07/06)
The introduction of a chlorine atom to a carbon center in an enantioselective manner via conventional C-Cl bond formation is difficult. Here we report a new approach to this class of tertiary alkyl chlorides with high optical purities. Instead of forming a new C-Cl bond, our approach involves carbene-catalyzed desymmetrization of 2-chloro-1,3-diols as the key step to set up the chiral carbon center with excellent enantiomeric excess.