321526-57-2

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 870-63-3 prenyl bromide 

Downstream Products

• 454180-55-3 (2S,5'S)-5'-(Benzyloxycarbamoyl-methyl)-4-((R)-1-ethoxycarbonyl-ethyl)-2,5'-diisobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 
• 321526-61-8 (2S,5'S)-5'-(2,2-Dimethoxy-ethyl)-2,5'-diisobutyl-4-[(R)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 
• 321526-64-1 (2S,5'S)-5'-Carboxymethyl-4-((R)-1-ethoxycarbonyl-ethyl)-2,5'-diisobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 
• 321526-63-0 (2S,5'S)-5'-(2,2-Dimethoxy-ethyl)-4-((R)-1-ethoxycarbonyl-ethyl)-2,5'-diisobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 
• 454180-54-2 (2S,5'S)-4-((R)-1-Carboxy-ethyl)-5'-(2,2-dimethoxy-ethyl)-2,5'-diisobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 
• 321526-62-9 (2S,5'S)-5'-(2,2-Dimethoxy-ethyl)-4-((R)-2-hydroxy-1-methyl-ethyl)-2,5'-diisobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid dibenzyl ester 

Relevant academic research and scientific papers

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Design, Synthesis, and Evaluation of a Pyrrolinone-based Matrix Metalloprotease Inhibitor

formula presented A pyrrolinone-based hydroxamate matrix metalloprotease inhibitor, (-)-1, has been designed and synthesized. Enzymatic assay revealed that (-)-1 inhibited three of the ten matrix metalloprotease enzymes examined and as such represents a n