32153-16-5

Usage

Type of compound

Amide derivative

Parent compounds

Benzylamine and phenylacetic acid

Common use

Pharmaceutical research (potential drug candidate)

Analgesic

Pain-relieving

Anti-inflammatory

Reduces inflammation

Potential applications

a. Treating chronic pain
b. Treating inflammation

Research focus

Mechanism of action and therapeutic uses

Field

Drug research and development

Upstream product

• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 67067-96-3 ethyl ester of N-benzyl-α-phenylglycine 
• 780-25-6 N-benzylidene benzylamine 
• 32153-18-7 2-(benzylamino)-2-phenylacetonitrile 
• 56249-50-4 (Benzyl-trimethylsilanyl-amino)-phenyl-acetonitrile 

Downstream Products

• 78139-29-4 2-methyl-4-phenyl-1,2,5-thiadiazol-3-one 
• 78139-30-7 3-Methoxy-4-phenyl-[1,2,5]thiadiazole 
• 2835-06-5 phenylglycin 
• 1859-51-4 N-Benzyl-α-phenylglycine 
• 5728-12-1 4-phenyl-[1,2,5]thiadiazol-3-ol 

Relevant academic research and scientific papers

Mechanochemical Activation of Iron Cyano Complexes: A Prebiotic Impact Scenario for the Synthesis of α-Amino Acid Derivatives

Mechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN, which can be trapped and incorporated into α-aminonitriles. This prebiotic impact scenario can be extended by mechanochemically transforming the resulting α-aminonitriles into α-amino amides using a chemical route related to early Earth conditions.

Stereoselective quaternization of α-amino phenylacetonitriles mediated by a remote sulfinyl group

(Chemical Equation Presented) Enantiomerically pure α-substituted α-amino phenylacetonitriles have been readily prepared from 2-p-tolylsulfinylbenzaldimines following a two-step sequence: a moderately stereoselective hydrocyanation of the imines and a com

AZOLE DERIVATIVES WITH ANTIMUSCARINIC ACTIVITY

The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.

A facile synthesis of substituted phenylglycines

A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.

Studies on Mesoionic Compounds. Part 10. Synthesis and Chemical Properties of Mesoionic 1,2,5-Thiadiazolium-3-olates

The preparation of a novel mesoionic heterocycle is described; derivatives of 4-aryl-5-alkyl-1,2,5-thiadiazolium-3-olates (6a-f) are obtained by treatment of α-N-substituted aminophenylacetamides with sulphur monochloride followed by base.