321574-22-5

Upstream product

• 436807-00-0 (2R)-2-((3aS,11cR)-3a,11c-dihydro-3H-benzo[5,6]chromeno[4,3-c]isoxazol-1(4H)-yl)-2-phenylethanol 
• 436806-96-1 (2R)-1-[(Z)-{[2-(allyloxy)-1-naphthyl]methylene}(oxido)amino]-2-phenylethanol 
• 436807-21-5 [(1R,2R)-1-amino-2,3-dihydro-1H-benzo[f]chromen-2-yl]methanol 
• 436807-20-4 (3aS,11cR)-1,3a,4,11c-tetrahydro-3H-benzo[5,6]chromeno[4,3-c]isoxazole 
• 19530-43-9 2-allyloxy-1-naphthaldehyde 
• 1840-19-3 1-isothiocyanato-3-trifluoromethyl-benzene 
• 436807-22-6 [(1R,2R)-1-(methylamino)-2,3-dihydro-1H-benzo[f]chromen-2-yl]methanol 

Relevant academic research and scientific papers

A stereoselective intramolecular 1,3-dipolar nitrone cycloaddition for the synthesis of substituted chromanes

A stereoselective intramolecular 1,3-dipolar nitrone cycloaddition useful in the synthesis of chromanes is described. The reaction relies on the use of a chiral auxiliary on the nitrone partner. Key to the success of the reaction is the choice of auxiliary and the choice of Lewis acid catalyst. Utilizing an auxiliary with a pendant coordinating group, and Zn(OTf)2 as the Lewis acid, diastereoselectivities up to 22:1 could be achieved.