321595-50-0Relevant academic research and scientific papers
Synthesis of symmetrical bis-steroid pyrazines connected via D-rings
Cerny, Ivan,Pouzar, Vladimir,Budesinsky, Milos,Drasar, Pavel
, p. 1597 - 1608 (2000)
Bis-steroid pyrazines fused through rings D of the steroid skeleton were synthesized. Methods for the preparation of the corresponding rings A fused derivatives (cephalostatin type) were checked on simple androstanes and then a symmetrical D fused analogue, 5α-androstano[16″,17″-5′,6′]pyrazino[2′, 3′-16,17]-5α-androstane-3β,3″β-diol, was prepared. Partially substituted bis-steroid pyrazines in both series were prepared and their use for the preparation of higher fused compounds was discussed. No significant cytostatic activity was found on parent bis-steroid pyrazines both A and D fused.
Steroid purine nucleoside analogue containing 1,2,3-triazole as well as preparation method and application thereof
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Paragraph 0062; 0063; 0064, (2017/10/22)
The invention belongs to the technical field of medical chemistry and relates to a steroid purine nucleoside analogue containing 1,2,3-triazole as well as a preparation method and application thereof. The steroid purine nucleoside analogue has a following general formula: the formula is shown in the description. The steroid purine nucleoside analogue is prepared by taking 3beta-hydroxy-5alpha-androstan-17-ketone or 4-aza-5alpha-androstan-3,17-dione as a raw material through bromination, oxidization, azidation and cycloaddition reaction; the preparation method is simple and has moderate conditions; the total yield of targets reaches 75 percent or more. The compound provided by the invention has a remarkable inhibition effect on cell lines of prostatic carcinoma, gastric carcinoma and the like and a leading compound structure is provided for further research of anti-cancer medicines, so that the variety of the steroid purine nucleoside analogue is enriched.
