321656-99-9

Upstream product

• 797762-16-4 5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-2-[(E)-[1,3]dioxolan-2-ylmethylimino]-5-methylimidazolidin-4-one 
• 321723-65-3 3-(4-bromo-benzyl)-1-(3,5-dichloro-phenyl)-3-methyl-1H-imidazo[1,2-a]imidazol-2-one 
• 213209-22-4 5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-2-thioxoimidazolidin-4-one 
• 213202-98-3 ethyl 2-amino-2-(4-bromobenzyl)-propanoate 
• 6590-93-8 3,5-dichlorophenylisothiocyanate 
• 321724-15-6 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5,6-diiodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 

Relevant academic research and scientific papers

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives

A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inhibito