321657-07-2

Upstream product

• 321656-73-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 688756-06-1 (S)-2-[(R)-5-(4-bromo-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-N-(2-hydroxy-ethyl)-propionamide 
• 1354344-46-9 (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-5-(piperazine-1-sulfonyl)-1H-imidazo[1,2-a]imidazol-2-one 
• 321657-64-1 4-[(R)-5-(4-bromobenzyl)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1354344-69-6 (R)-5-(1-[⁽²⁾H₈]-piperazinylsulfonyl)-1-(3,5-dichlorophenyl)-3-[4-(5-pyrimidinyl)benzyl]-3-methyl-1H-imidazo[1,2-a]imidazol-2-one 
• 1354344-64-1 (R)-5-(1-piperazinylsulfonyl)-1-(3,5-dichlorophenyl)-3-[4-(5-(2-[⁽¹⁴⁾C]-pyrimidinyl))benzyl]-3-methyl-1H-imidazo[1,2-a]imidazol-2-one 
• 321719-29-3 4-[(R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5(4-pyrimidin-5-ylbenzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1354344-43-6 4-{(R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-[[4-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]methyl]-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl}piperazine-1-carboxylic acid tert-butyl ester 
• 321719-03-3 C₁₉H₁₅BrCl₂N₄O₃S 
• 321721-20-4 C₁₉H₁₄BrCl₂N₃O₄S 

Relevant academic research and scientific papers

Synthesis of potent lymphocyte function-associated antigen-1 inhibitors labeled with carbon-14 and deuterium, part 1

The lymphocyte function-associated antigen-1 (LFA-1) is an essential component in normal immune system function and is a target for drug discovery for its broad therapeutic potential in treating inflammatory diseases. Here, we report the synthesis of thre

Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

Disclosed is an improved multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a] IMIDAZOLE-3-SULFONIC ACID

Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a res

DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-SULFONYLAMINO]-PROPIONAMIDE

Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.