321707-21-5Relevant articles and documents
Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1 inhibitors
He, Haifeng,Feng, Jiangtao,He, Junbo,Xia, Qin,Ren, Yanliang,Wang, Fang,Peng, Hao,He, Hongwu,Feng, Lingling
, p. 4310 - 4320 (2016)
In this study, a series of novel amide derivatives and sulfamide derivatives as potential E. coli PDHc E1 inhibitors were designed and synthesized by optimizing the linker between triazole and benzene ring moieties based on the structure of lead compound
Alternating Cascade Metathesis Polymerization of Enynes and Cyclic Enol Ethers with Active Ruthenium Fischer Carbenes
Sui, Xuelin,Zhang, Tianqi,Pabarue, Alec B.,Fu, Liangbing,Gutekunst, Will R.
, p. 12942 - 12947 (2020)
Ruthenium alkoxymethylidene complexes have rarely been demonstrated as active species in metathesis reactions and are frequently regarded as inert. Herein, we highlight the ability of these Fischer-type carbenes to participate in cascade alternating ring-
Ruthenium Carbene-Mediated Construction of Strained Allenes via the Enyne Cross-Metathesis/Cyclopropanation of 1,6-Enynes
Gao, Ming,Gao, Qiangqiang,Hao, Xiangbin,Wu, Ying,Zhang, Qingmin,Liu, Guohua,Liu, Rui
supporting information, p. 1139 - 1143 (2020/02/15)
Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl2(PPh3)3, which results in a series of bicyclo[3.1.0]hexyl allene derivatives in moderate to excellent yields. Mechanistic investigation indicates that the in-situ-generated ruthenium vinylidene undergoes a site-selective metathesis process to provide allenyl ruthenium carbene, which can be intramolecularly trapped by the pendent C=C bond of enyne through a [2 + 2] cycloaddition/metal elimination process.
Orthogonal Syntheses of 3.2.0 Bicycles from Enallenes Promoted by Visible Light
Serafino, Andrea,Balestri, Davide,Marchiò, Luciano,Malacria, Max,Derat, Etienne,Maestri, Giovanni
supporting information, p. 6354 - 6359 (2020/09/02)
Enallenes can be readily converted into two families of 3.2.0 (hetero)bicycles with high diastereoselectivities through the combination of visible light with a suitable Ir(III) complex (1 mol percent). Two complementary pathways, namely, a photocycloaddit
Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1
Feng, Jiangtao,He, Haifeng,Zhou, Yuan,Cai, Meng,Peng, Hao,Liu, Honglin,Liu, Lei,Feng, Lingling,He, Hongwu
, (2019/11/14)
Harmful cyanobacteria bloom (HCB) has occurred frequently in recent years and it is urgent to develop novel algicides to deal with this problem. In this paper, a series of novel thiamin diphosphate (ThDP) analogs 5a?5g were designed and synthesized target
