321724-08-7

Upstream product

• 321657-06-1 (R)-3-(4-cyanobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-imidazo[1,2-a]-imidazol-2-one 
• 835917-11-8 {[2-(4-cyano-phenyl)-1-(3,5-dichloro-phenylcarbamoyl)-1-methyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 835917-09-4 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile 
• 835917-15-2 3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-2-(5-oxo-2-thioxo-imidazolidin-1-yl)-propionamide 
• 835917-13-0 2-(2-amino-acetylamino)-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide 
• 835917-16-3 4-[1-(3,5-dichloro-phenyl)-3-methyl-2,5-dioxo-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazol-3-ylmethyl]-benzonitrile 
• 321724-11-2 2-amino-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide 
• 341027-25-6 (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one 
• 17201-43-3 4-cyanobenzyl bromide 
• 835917-17-4 phosphoric acid 5-(4-cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazol-3-yl ester diethyl ester 

Downstream Products

• 688756-08-3 (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl chloride 

Relevant academic research and scientific papers

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines

DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONYL]-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE

Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease