835917-09-4Relevant articles and documents
A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins
Wang, Xiao-Jun,Zhang, Li,Xu, Yibo,Krishnamurthy, Dhileepkumar,Varsolona, Richard,Nummy, Laurence,Shen, Sherry,Frutos, Rogelio P.,Byrne, Denis,Chung,Farina, Vittorio,Senanayake, Chris H.
, p. 273 - 276 (2005)
An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a-b serves as a key step to highly functionalized bicyclic guanidines