321848-65-1

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 716368-88-6 2-bromo-N-(1-hydroxymethyl-2-methyl-propyl)-benzamide 

Downstream Products

• 716368-91-1 (4R)-isopropyl-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole 
• 1340476-89-2 (4S)-4,5-dihydro-2-[2'-(2,6-dimethylanilino)phenyl]-4-isopropyloxazole 
• 104713-12-4 (1S)-1-phenylprop-2-en-1-ol 
• 104713-12-4 (R)-1-phenylprop-2-en-1-ol 

Relevant academic research and scientific papers

A N, N - [...] rare earth metal complex, preparation method and application (by machine translation)

The present invention provides a N, N - [...] rare earth metal complex, preparation method and application, which belongs to the technical field of catalysis. The N, N - [...] ligand, in order to contain different chiral substituent amino alcohol and bromo benzoic acid as a starting raw material, the raw materials are easy to get and easy to modify; N, N - [...] rare earth metal complex preparation method, comprising different chiral substituent N, N - [...] ligand can be directly with the rare earth metal reaction, separation and purification of the catalyst, the yield is high; N, N - [...] rare-earth metal complexes can be directly used for catalytic ε - caprolactone, L - lactide, rac - lactide, meso - lactide, β - butyrolactone and carbonate and the like and its derivatives of the cyclic ring-opening polymerization reaction, has high catalytic activity, can obtain high molecular weight and a narrow molecular weight distribution of the polymer, thereby obtaining a series having a specific structure of the high-molecular material. (by machine translation)

Unprecedented Formation of π-Copper Complexes during Sonogashira Coupling: Synthesis of a Unique, Recyclable, Ethynyl Ferrocene Derived Cu(I) Specific Ligand

During the synthesis of a chiral oxazolinyl-derived ethynyl ferrocene {Fc-C≡C-C6H4-o-(4-iPr-2-Ox)} (Fc = ferrocenyl; Ox = oxazolinyl), we observed an unprecedented formation of highly air stable and monomeric π-copper(I) complexes 4a and 4b, which were structurally characterized. CuI was used as a cocatalyst in this Sonogashira coupling. By the reaction of 4a with aqueous NH3/DMF, the CuI was removed from the complex and the metal-free compound 5a was obtained. This was found to be an excellent ligand for selectively binding Cu(I) halides. Analogous 4-Ph-substituted oxazoline-based ligand 5b and its Cu-I complex 4c were also isolated and characterized. The possible role of these complexes in explaining the copper cycle proposed for Sonogashira coupling has also been discussed.

Vanadium-catalyzed selenide oxidation with in situ [2,3] sigmatropic rearrangement (SOS reaction): Scope and asymmetric applications

A vanadium-catalyzed method for the oxidation of prochiral aryl, allylic selenides with tandem sigmatropic rearrangement has been developed. This protocol has been screened on a series of substrates to test for its generality and effectiveness. The applicability of this methodology to the synthesis of enantiomerically enriched allylic alcohols has been studied on a series of chiral oxazole-containing systems with a diastereomeric ratio (d.r.) of up to 85 : 15. The chiral transfer observed in the allyl alcohol products is the result of a net 1,9- and/or 1,10-induction. Finally, the first example of a selenium-oxygen nonbonding interaction in oxazole-containing selenide appears to have been observed via X-ray crystal analysis.