321879-84-9

Upstream product

• 22071-15-4 ketoprofen 
• 57872-48-7 ketoprofen methyl ester 
• 107-21-1 ethylene glycol 

Downstream Products

• 863225-02-9 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2S)-2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 
• 863225-01-8 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2R)-2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 
• 863224-92-4 2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionic acid 
• 863224-89-9 methyl 2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 
• 863225-12-1 methyl 2-fluoro-2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propionate 

Relevant academic research and scientific papers

Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

HETEROAROMATIC RING COMPOUNDS

Heteroaromatic ring compounds or pharmaceutically acceptable salts thereof, which have excellent characteristics and have strong curative effects to immuno-imbalance and choronic inflammation. Representative is the compound of the formula: