863224-92-4

Upstream product

• 1020533-81-6 2-[3-(1,1-difluoroethyl)phenyl]-2-phenyl-1,3-dioxane 
• 124-38-9 carbon dioxide 
• 22071-15-4 ketoprofen 
• 863225-12-1 methyl 2-fluoro-2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propionate 
• 321879-84-9 methyl 2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propionate 
• 863224-89-9 methyl 2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 

Downstream Products

• 863225-01-8 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2R)-2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 
• 863225-02-9 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2S)-2-fluoro-2-[3-(phenylcarbonyl)phenyl]propionate 

Relevant academic research and scientific papers

Electrochemical carboxylation of α,α-difluorotoluene derivatives and its application to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs

Electrochemical carboxylation of α,α-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding α-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs). Georg Thieme Verlag Stuttgart.

Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.