321915-72-4Relevant academic research and scientific papers
Synthesis of [thiazolium-2,2′-14C2]-SAR97276A from [14C]-thiourea
Herbert, John M.,Le Strat, Franck,Oumeddour, Delphine G.,Passey, Stephen C.,Taylor, Keith,Whitehead, David M.
, p. 89 - 92 (2011/10/02)
[thiazolium-2,2′-14C2]-SAR97276A, a bis(thiazolium) antimalarial development candidate, was synthesized from [ 14C]-thiourea with an overall radiochemical yield of 15%. The synthetic route involves a modified procedure for the synthesis of [ 14C]-sulfurol, also a key intermediate in thiamine synthesis, which was developed due to unlabelled chemistry proving irreproducible with the radiolabelled substrate. Copyright
Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity
-
Page/Page column 17, (2010/02/14)
The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A′, identical or different, are respectively either a group A1 and A′1 of formula (1)
