321971-04-4Relevant academic research and scientific papers
An improved protocol for the SmI2-promoted C-alkylation of peptides: Degradation and functionalization of serine residues in linear and cyclic peptides
Blakskj?r, Peter,Gavrila, Adina,Andersen, Lisbeth,Skrydstrup, Troels
, p. 9091 - 9094 (2007/10/03)
The utility of the samarium diiodide promoted C-alkylation of peptides for the introduction of new side chains on peptide strands is dramatically enhanced by the initial oxidative degradation of serine residues in small peptides. In this way, cyclic pepti
Selective side chain introduction onto small peptides mediated by samarium diiodide: A potential route to peptide libraries
Ricci,Blakskjaer,Skrydstrup
, p. 12413 - 12421 (2007/10/03)
A mild and simple method for the selective introduction of carbinol side chains onto glycine residues in peptides is presented as a potential route for the preparation of peptide libraries. A series of di- and tripeptides, as well as one tetrapeptide, eac
