6206-42-4

Basic information

• Product Name: methyl N-[(benzyloxy)carbonyl]glycylphenylalaninate
• Synonyms: N-benzyloxycarbonyl-glycyl-phenylalanine methyl ester
• CAS NO: 6206-42-4
• Molecular Formula: C₂₀H₂₂N₂O₅
• Molecular Weight: 370.3991
• Mol File: 6206-42-4.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 595.4°C at 760 mmHg
• Flash Point: 313.9°C
• Density: 1.218g/cm³
• Vapor Pressure: 3.83E-14mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: methyl N-[(benzyloxy)carbonyl]glycylphenylalaninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-[(benzyloxy)carbonyl]glycylphenylalaninate(6206-42-4)
• EPA Substance Registry System: methyl N-[(benzyloxy)carbonyl]glycylphenylalaninate(6206-42-4)

Safety Data

• Hazardous Substances Data: 6206-42-4(Hazardous Substances Data)

Upstream product

• 4024-42-4 1-(N-benzyloxycarbonyl-glycyloxy)-piperidine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 501-53-1 benzyl chloroformate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 1330059-26-1 N-benzyloxycarbonylglycine 9-fluorenylmethyl thioester 
• 16707-70-3 2-(((benzyloxy)carbonyl)amino)ethanethioic S-acid 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 67-56-1 methanol 
• 101399-00-2 (S)-tert-butyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 
• 2899-60-7 Cbz-Gly-ONSuc 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 5680-83-1 N-(benzyloxycarbonyl)glycine hydrazide 
• 3081-24-1 H-Phe-OEt 

Downstream Products

• 1170-76-9 Z-Gly-(L)-Phe 
• 69193-15-3 N-(benzyloxycarbonyl)-glycyl-L-phenylalanyl-L-leucine amide 
• 19240-24-5 N--L-3-phenylalanine methyl ester hydrochloride 
• 78674-40-5 glycyl-N-methyl-L-phenylalaninamide, hydrochloride 
• 321971-04-4 (S)-2-[2-Benzyloxycarbonylamino-2-(pyridin-2-ylsulfanyl)-acetylamino]-3-phenyl-propionic acid methyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 17942-42-6 Cbz-glycylphenylalanyl hydrazide 
• 16227-22-8 glycyl-L-phenylalanine methyl ester 
• 1013423-57-8 methyl 3-(dimethylamino)-2-(4-benzyl-2,5-dioxoimidazolidin-1-yl)propenoate 

Relevant articles and documents

Continuous synthesis of a tripeptide by successive condensation and transesterification catalyzed by two immobilized proteinases in organic solvent.

The tripeptide Z-GlyPheLeuNH2 was continuously synthesized in a high yield from three amino acid derivatives, Z-Gly, PheOMe, and LeuNH2, by immobilized thermolysin (IMT) and immobilized alpha-chymotrypsin (IMC) in an organic solvent, ethyl acetate. The op

Phosphorus pentoxide for amide and peptide bond formation with minimal by-products

Phosphorus pentoxide and DMAP are used for amide bond formation from carboxylic acids and amines. Dipeptides and amides have been synthesized using this reagent in 42–77% yields and >99% ees. The protocol is attractive as it occurs at ambient temperature, the formation of organic by-products is minimal and the reagent can be readily quenched using water. Furthermore, excellent enantioselectivities are observed without the use of harsh triazole based additives.

Pd-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides: Synthesis of indoline-2-carboxylate-containing dipeptides

A palladium-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides is described. By this protocol, a series of indoline-2-carboxylate-containing dipeptides were synthesized from dipeptides. The N-protected amino aci