321985-22-2

Upstream product

• 78-82-0 Isobutyronitrile 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 10489-28-8 2,2-dimethyl-indan-1-one 
• 278615-08-0 3-(2-bromophenyl)-2,2-dimethylpropanal 
• 92367-59-4 3,3-dimethyl-3,4-dihydroquinolin-2(1H)-one 
• 149080-24-0 3-(2-bromophenyl)-2,2-dimethylpropanoic acid 
• 1430115-67-5 benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430115-68-6 benzyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430564-00-3 benzyl 3,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430564-01-4 benzyl 5-hydroxy-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430564-02-5 benzyl 5-(1-(tert-butoxycarbonyl)piperidine-4-yloxy)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant academic research and scientific papers

GUANIDINE AND AMINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): (Formula (I)) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles

An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.

Pd-catalyzed intramolecular acylation of aryl bromides via C-H functionalization: A highly efficient synthesis of benzocyclobutenones

(Chemical Equation Presented) A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows fo