278615-08-0

Upstream product

• 78-84-2 isobutyraldehyde 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 321985-22-2 3-(2-bromophenyl)-2,2-dimethylpropanenitrile 

Downstream Products

• 910806-12-1 (E/Z)-ethyl-5-(2-bromophenyl)-4,4-dimethyl-2-ethoxypent-2-enoate 

Relevant academic research and scientific papers

Intramolecular Anti-Carbolithiation of Alkynes: Stereo-Directing Effect of Lithium-Coordinating Substituents

This paper presents the results of our investigations on the stereochemical course of intramolecular carbolithiation of alkynes. It is shown that the presence of a lithium-chelating propargylic substituent completely reverses the otherwise favored syn-pro

Intramolecular palladium(II)/(IV) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group

Palladium catalysed β-C(sp3)-H activation of tertiary aldehydes using a transient imine directing group enables intramolecular arylation to form substituted indane-aldehydes. A simple amine bearing a methyl ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives. Preliminary mechanistic studies identify a reversible C-H activation, product inhibition and suggest that oxidative addition is the turnover limiting step.

Pd-catalyzed intramolecular acylation of aryl bromides via C-H functionalization: A highly efficient synthesis of benzocyclobutenones

(Chemical Equation Presented) A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows fo

6, 7, 8, 9-TETRAHYDRO-5-AMINO-5H-BENZOCYCLOHEPTEN-6-OL DERIVATIVES AND RELATED COMPOUNDS USED AS ANTI-INFLAMMATORY AGENTS

The invention relates to polysubstituted 5H-benzocyclohepten derivatives of formula (I), in which R3 represents a C1-C10 alkyl group, which can be optionally substituted by a group selected from 1-3 hydroxy groups, halogen atoms, or 1-3 (C1-C5) alkoxy groups, an optionally substituted (C3-C7) cycloalkyl group, an optionally substituted heterocyclyl group, an optionally substituted aryl group, or other substituents, A represents a -CR6R7-CH2- or -CH2-CR6R7 group, D represents a -CR4R5-CH2- or -CH2-CR4R5 group, R4 represents a hydroxy group, an OR10 group or O(CO)R10 group, R5 represents a (C1-C5) alkyl group or an optionally partially or completely fluorinated (C1-C5) alkyl group, a (C3-C7) cycloalkyl group, a (C1-C8) alkene (C3-C7) cycloalkyl group, a (C2-C8) alkene (C3-C7) cycloalkyl group, a heterocyclyl group, a (C1-C8) alkene heterocyclyl group, a (C2-C8) alkene heterocyclyl group, an aryl group, a (C1-C8) alkene aryl group, a (C2-C8) alkenylene aryl group, a (C2-C8) alkynylene aryl group, or other substituents. Said other substituents are specified in the claims. The invention also relates to a method for producing said derivatives and to their use as anti-inflammatory agents.