3221-13-4

Basic information

• Product Name: 2-((4-bromophenoxy)methyl)thiirane
• Synonyms: 2-((4-bromophenoxy)methyl)thiirane
• CAS NO: 3221-13-4
• Molecular Weight: 245.14
• Mol File: 3221-13-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-((4-bromophenoxy)methyl)thiirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-bromophenoxy)methyl)thiirane(3221-13-4)
• EPA Substance Registry System: 2-((4-bromophenoxy)methyl)thiirane(3221-13-4)

Safety Data

• Hazardous Substances Data: 3221-13-4(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 2212-06-8 2-((4-bromophenoxy)methyl)oxirane 

Relevant articles and documents

NBS/DMSO-mediated synthesis of (2,3-dihydrobenzo[b] [1,4]oxathiin-3-yl)methanols from aryloxymethylthiiranes

(2,3-Dihydrobenzo[b][1,4]oxathiin-3-yl)methanols were synthesized via reactions of aryloxymethylthiiranes and N-bromosuccinimide (NBS) in DMSO under microwave irradiation. The reaction mechanism was proposed as an intramolecular aromatic electrophilic substitution of 1-bromo-2-(aryloxymethyl)thiiran-1-iums, generated from aryloxymethylthiiranes and NBS, and the subsequent DMSO nucleophilic ring opening reaction of thiiran-1-iums followed by the water displacement. The current method provides a direct and simple strategy in the efficient preparation of (2,3-dihydrobenzo[b][1,4]oxathiin-3-yl)methanols from readily available aryloxymethylthiiranes.