3221-17-8 Usage
Uses
Used in Pharmaceutical Development:
1-Piperazineethanol,4-propyl-(7CI,8CI,9CI) is used as a research chemical for the development of pharmaceuticals targeting the central nervous system. Its psychoactive properties and effects on neurotransmitter systems make it a valuable compound for studying and developing new treatments for various neurological and psychiatric disorders.
Used in Neurotransmitter System Research:
In the field of neuroscience, 1-Piperazineethanol,4-propyl-(7CI,8CI,9CI) is used as a research tool to investigate the mechanisms and functions of neurotransmitter systems. Understanding the interactions of 1-Piperazineethanol,4-propyl-(7CI,8CI,9CI) with neurotransmitters can provide insights into the development of new therapeutic approaches for neurological conditions.
Used in Central Nervous System Studies:
1-Piperazineethanol,4-propyl-(7CI,8CI,9CI) is utilized in research aimed at understanding the structure and function of the central nervous system. Its role as a central nervous system depressant allows scientists to explore its effects on cognitive functions, mood regulation, and other related aspects, potentially leading to advancements in the treatment of CNS-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 3221-17-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,2 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3221-17:
(6*3)+(5*2)+(4*2)+(3*1)+(2*1)+(1*7)=48
48 % 10 = 8
So 3221-17-8 is a valid CAS Registry Number.
3221-17-8Relevant academic research and scientific papers
Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines
Lemaitre, Stephane,Lepailleur, Alban,Bureau, Ronan,Butt-Gueulle, Sabrina,Lelong-Boulouard, Veronique,Duchatelle, Pascal,Boulouard, Michel,Dumuis, Aline,Daveu, Cyril,Lezoualc'h, Frank,Pfeiffer, Bruno,Dauphin, Francois,Rault, Sylvain
scheme or table, p. 2607 - 2622 (2009/09/06)
Based on the definition of a 5-HT4 receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT4 receptors. The compounds were synthesized by substituting the chlorine atom of the pyrazine ring with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [3H]GR113808 (1) as the 5-HT4 receptor radioligand. The affinity values (Ki or inhibition percentages) were affected by both the substituent on the aromatic ring and the substituent on the lateral piperidine chain. A methyl group on the tricyclic ring produced a marked increase in affinity while an N-propyl or N-butyl group gave compounds with nanomolar affinities. Among the most potent ligands, 34d was selected for further pharmacological studies and evaluated in vivo. This compound acts as an antagonist/weak partial agonist in COS-7 cells stably expressing the 5-HT4(a) receptor and is of great interest as a peripheral antinociceptive agent.
