32213-47-1Relevant articles and documents
Erythro-Directive Reduction of α-Substituted Alkanones by Means of Hydrosilanes in Acidic Media
Fujita, Makoto,Hiyama, Tamejiro
, p. 5415 - 5421 (2007/10/02)
Hydrosilane reduced α-oxy and α-amino ketones and β-keto acid derivatives in trifluoroacetic acid to afford the corresponding erythro alcohols with high diastereoselectivity.The reaction proceeded without racemization at the carbon α to the carbonyl group.The erythro-directive reduction was explained in terms of the proton-bridged Cram cyclic model and successfully applied to the synthesis of physiologically important amino alcohols such as l-ephedrine, l-methoxamine, and erythro-2-methyl-3-piperidino-1-phenylpropanol.
Highly Stereoselective Reduction of α-Substituted β-Keto Amides by Means of Hydrosilane/F- and Hydrosilane/H+ Reagent. A Practical Approach to Aldols of Both Threo and Erythro Configurations
Fujita, Makoto,Hiyama, Tamejiro
, p. 8294 - 8296 (2007/10/02)
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