32219-80-0Relevant academic research and scientific papers
Tandem Michael-Wittig Horner reaction one-pot synthesis of δ-substituted α,β-unsaturated esters
Piva, Olivier,Comesse, Sebastien
, p. 7191 - 7194 (1997)
A direct synthesis of δ-substituted α,β-unsaturated esters from unsubstituted aldehydes or ketones has been accomplished in high yield by a tandem 1,4-addition and Wittig-Horner reaction. The Copper-enolate obtained after the first step was able to deprotonate the highly addic phosphonate generating thus the two components necessary for the second coupling reaction.
