Tetrahedron Letters p. 7191 - 7194 (1997)
Update date:2022-07-29
Topics:
Piva, Olivier
Comesse, Sebastien
A direct synthesis of δ-substituted α,β-unsaturated esters from unsubstituted aldehydes or ketones has been accomplished in high yield by a tandem 1,4-addition and Wittig-Horner reaction. The Copper-enolate obtained after the first step was able to deprotonate the highly addic phosphonate generating thus the two components necessary for the second coupling reaction.
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