32223-72-6Relevant academic research and scientific papers
Oxime Carbamate-Discovery of a series of novel FAAH inhibitors
Sit,Conway, Charles M.,Xie, Kai,Bertekap, Robert,Bourin, Clotilde,Burris, Kevin D.
supporting information; experimental part, p. 1272 - 1277 (2010/06/17)
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.1.
A family of hydrogels based on ureido-linked aminopolyol-derived amphiphiles and bolaamphiphiles: Synthesis, gelation under thermal and sonochemical stimuli, and mesomorphic characterization
Avalos, Martin,Babiano, Reyes,Cintas, Pedro,Gomez-Carretero, Antonio,Jimenez, Jose L.,Lozano, Marina,Ortiz, Angel L.,Palacios, Juan C.,Pinazo, Aurora
experimental part, p. 5656 - 5669 (2009/06/05)
This article describes the systematic preparation of a novel family of carbohydrate amphiphiles and bolaamphiphiles in which hydrophilic and hydrophobic units are connected via a ureido or bis(ureido) moiety. The sugar core is derived from aminopolyols such as D-glucamine (1), N-methyl-D-glucamine (2), or the sugar-like species tris(hydroxymethyl)aminomethane (3). The O-unprotected derivatives behave as self-organizing nonionic surfactants with good water gelation ability, which can be induced under thermal or ultra-sound-driven stimuli. In addition, some derivatives of 1 and 2, and rarely 3 also formed lyotropic liquid crystals with lamellar or hexagonal structures that exhibit low-temperature transitions.
Comparison of base-promoted and self-catalyzed conditions in the synthesis of isocyanates from amines using triphosgene
Charalambides, Yiannis C.,Moratti, Stephen C.
, p. 1037 - 1044 (2007/10/03)
Comparison of base-promoted and self-catalyzed conditions for the synthesis of isocyanates from amines and triphosgene shows no advantage in using an amine base in the majority of cases. The workup and isolation of the product is simplified under base-free conditions. Yields of between 50 and 90% after distillation were common. Only acid-sensitive substrates need a base catalyst. Copyright Taylor & Francis Group, LLC.
