3223-55-0Relevant academic research and scientific papers
I2-TBHP-catalyzed one-pot highly efficient synthesis of 4,3-fused 1,2,4-triazoles from: N -tosylhydrazones and aromatic N-heterocycles via intermolecular formal 1,3-dipolar cycloaddition
Inturi, Surendra Babu,Kalita, Biswajit,Ahamed, A. Jafar
supporting information, p. 11061 - 11064 (2016/12/07)
I2-TBHP-catalyzed azomethine imine generation and subsequent regioselective 1,3-dipolar cycloaddition (DC) with aromatic N-heterocycles was developed to afford various 4,3-fused 1,2,4-triazoles in excellent yields. The method is operationally simple and highly efficient with broad functional group tolerance.
Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
Li, Ertong,Hu, Zhiyuan,Song, Lina,Yu, Wenquan,Chang, Junbiao
, p. 11022 - 11027 (2016/07/27)
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio
Palladium-catalyzed coupling of aldehyde-derived hydrazones: Practical synthesis of triazolopyridines and related heterocycles
Thiel, Oliver R.,Achmatowicz, Michal M.,Reichelt, Andreas,Larsen, Robert D.
supporting information; experimental part, p. 8395 - 8398 (2010/12/25)
The palladium-catalyzed intermolecular coupling of aldehyde-derived hydrazones with chloroazines, followed by oxidative cyclization under mild conditions afforded access to a broad variety of bicyclic heterocyclic scaffolds (see scheme) that have potentia
The Preparation of 3-Phenyltriazolopyridines and Their Benzologs from N-(Phenylsulfonyl)benzohydrazonoyl Chloride and Pyridines
Ito, Suketaka,Kakehi, Akikazu,Matsuno, Toshiyuki,Yoshida, Jun-ichi
, p. 2007 - 2011 (2007/10/02)
3-Phenyltriazolopyridines were obtained in good yields from N'-benzenesulfonohydrazidates, generated from 2-unsubstituted pyridines and N-(phenylsulfonyl)benzohydrazonoyl chloride (2), by oxidation with chloranil.The reaction of quinoline and isoquinoline with 2 gave 1-phenyl-3-phenylsulfonyl-3,3a-dihydrotriazoloquinoline and 3-phenyl-1-phenylsulfonyl-1,10b-dihydrotriazoloisoquinoline respectively, both in good yields; they aromatized to the corresponding triazoles by the 1,2-elimination of benzenesulfinic acid on heating.
