32251-82-4

Upstream product

• 100-39-0 benzyl bromide 
• 107073-66-5 α,γ-dipyrrolidinylglutaronitrile 
• 181214-43-7 (4,4-dibromobut-3-en-1-ynyl)benzene 
• 181214-48-2 [(Z)-4-bromobut-3-en-1-ynyl]benzene 
• 204651-50-3 [(Z)-4-iodobut-3-en-1-ynyl]benzene 
• 2579-22-8 Phenylpropargyl aldehyde 
• 91272-98-9 1-(1-pyrrolidinomethyl)-pyrazole 

Relevant academic research and scientific papers

TRICYCLIC COMPOUNDS

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Domino Cu-catalyzed C-N coupling/hydroamidation: A highly efficient synthesis of nitrogen heterocycles

(Chemical Equation Presented) Working in tandem: Highly functionalized pyrroles and pyrazoles can be synthesized from a domino Cu-catalyzed C-N coupling/hydroamidation sequence. The scope and the generality of the method is noteworthy as a wide variety of substituents, either in the alkene or alkyne counterparts, are well tolerated.

Synthesis of 2-Substituted Imidazoles and Benzimidazoles and of 3-Substituted Pyrazoles by Lithiation of N-(Dialkylamino)methyl Heterocycles

The lithiation of N-(dialkylamino)methyl (aminal) derivatives of imidazole, benzimidazole, and pyrazole (themselves readily available from parent heterocycles, formaldehyde, and a secondary amine) occurs smoothly at 2-, 2-, and 5-positions, respectively, upon treatment with n-butyllithium in ether or tetrahydrofuran.Reaction with electrophiles, and subsequent facile acid-catalyzed hydrolysis of the protecting group, provides 2-substituted imidazoles, 2-substituted benzimidazoles, and 3(5)-substituted pyrazoles in good overall yields.

A NEW SYNTHESIS OF 3,5-DISUBSTITUTED PYRAZOLES BY REACTION OF α,γ-DIPYROLIDINYLGLUTARONITRILES (MASKED α,γ-DIKETONE EQUIVALENTS) WITH HYDRAZINES

An efficient sequence proposed for a new synthetic method of 3,5-disubstituted pyrazoles involves the reaction of α,γ-dipyrolidinylglutaronitriles (masked α,γ-diketone equivalents) with hydrazines.