3226-46-8

Basic information

• Product Name: 3-Chloro-4-thiocyanatoaniline
• Synonyms: 3-Chloro-4-thiocyanatoaniline;Thiocyanic acid, 4-amino-2-chlorophenyl ester
• CAS NO: 3226-46-8
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.646
• Mol File: 3226-46-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 60-61 °C
• Boiling Point: 319.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 1.88±0.10(Predicted)
• CAS DataBase Reference: 3-Chloro-4-thiocyanatoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-thiocyanatoaniline(3226-46-8)
• EPA Substance Registry System: 3-Chloro-4-thiocyanatoaniline(3226-46-8)

Safety Data

• Hazardous Substances Data: 3226-46-8(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-thiocyanatoaniline is a chemical compound that is classified as an aromatic amine. Its molecular formula is C7H5ClN2S, and it contains a chlorine atom, a thiocyanate group, and an aniline group. It is used in the production of dyes and pigments and has applications in the textile and pharmaceutical industries. The compound is a white to pale yellow solid at room temperature and is insoluble in water but soluble in organic solvents. It is important to handle 3-Chloro-4-thiocyanatoaniline with caution as it may be harmful if swallowed, inhaled, or in contact with skin, and it may cause irritation to the respiratory system and skin.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 108-42-9 3-chloro-aniline 
• 408350-99-2 2-chloro-4-nitro-phenyl thiocyanate 

Downstream Products

• 21959-87-5 N-<3-Chlor-4-thiocyanato-phenyl>-N'--harnstoff 
• 56311-69-4 3'-Chlor-4'-thiocyanato(2,4,5-trichlorphenoxy)acetanilid 
• 23745-23-5 Cyclopropanecarboxylic acid (3-chloro-4-thiocyanato-phenyl)-amide 
• 56311-73-0 1-Phenyl-3-(3-chlor-4-isothiocyanatophenyl)harnstoff 
• 56311-66-1 3'-Chloro-4'-thiocyanatophenoxyacetanilid 
• 7263-32-3 N-Aethoxycarbonylmethyl-N'-(3-chlor-4-thiocyanato-phenyl)-harnstoff 
• 61994-07-8 3'-chloro-4'-thiocyanatohydrocinnamanilide 
• 56311-67-2 3'-Chlor-4'-thiocyanato(p-chlorphenoxy)acetanilid 
• 56311-75-2 N-(4-Chlorobenzyliden)-3-chlor-4-thiocyanatoanilin 

Relevant articles and documents

ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light

An ARS-TiO2 photocatalyst has been prepared, by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark, to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazole, phenol, aniline, indole and pyrrole derivatives) were treated with the thiocyanate anion at room temperature. Herein, the first report on thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives under visible light is presented.

Visible light thiocyanation of: N -bearing aromatic and heteroaromatic compounds using Ag/TiO2 nanotube photocatalyst

In this study, Ag/TiO2 nanotubes (Ag/TNT) were synthesized via simple hydrothermal process, and this photocatalyst was successfully exploited in thiocyanation reactions at room temperature under visible light irradiation. Four classes of important heterocyclic compounds including indole, aniline, pyrrole and 2-amino thiazole derivatives via Ag/TNT treated with ammonium thiocyanate formed the corresponding thiocyano compounds in moderate to excellent yields. Plasmonic property and catalytic performance of Ag nanoparticles (which mainly deposited on the surface of TNT) in absorbing species containing sulfur atoms were key components for the reactions to proceed. This potent, simple and versatile protocol reported for the first time afforded thiocyanation reactions of aniline, pyrrole and 2-amino thiazole derivatives under visible light. The reactions proceeded through a radical pathway by applying air molecular oxygen as a low-cost and environmentally friendly terminal oxidant.

On the rhodanation of halogen substituted anilines. 24. On the organic rhodan compounds

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