907211-31-8Relevant articles and documents
First scale-up: Problems and resolutions on the synthesis of WAY-253752, a novel, dual-acting SSRI/5HT1A antagonist
Nikitenko, Antonia,Evrard, Deborah,Sabb, Annmarie L.,Vogel, Robert L.,Stack, Gary,Young, Mairead,Lin, Melissa,Harrison, Boyd L.,Potoski, John R.
, p. 76 - 80 (2012/12/31)
An alternative synthesis of WAY-253752, 1, a novel, dual-acting SSRI/5HT1A antagonist, was developed and used for the first scale-up. Initially, the target compound was synthesized as part of a diasteromeric mixture separated by chiral preparative HPLC. The new route was designed around intermediates suitable for chiral resolution, and its conditions were successfully determined.
