32278-29-8

Upstream product

• 26232-98-4 4,4-dimethyl-pent-2-ene 
• 564-04-5 2,2-dimethyl-3-pentanone 
• 7789-69-7 phosphorus pentabromide 
• 3970-62-5 2,2-dimethyl-3-pentanol 

Downstream Products

• 39489-62-8 4-(2,4-Dichloro-phenoxy)-2,2-dimethyl-pentan-3-one 
• 36677-29-9 (4SR,5SR)-5-hydroxy-5-phenyl-2,2,4-trimethyl-3-pentanone 
• 95573-26-5 erythro hydroxy-5 phenyl-7 tetramethyl-2,2,4,5 heptene-6 one-3 
• 95573-26-5 threo hydroxy-5 phenyl-7 tetramethyl-2,2,4,5 heptene-6 one-3 
• 51503-04-9 erythro diphenyl-5,7 hydroxy-5 trimethyl-2,2,4 heptene-6 one-3 
• 51503-04-9 threo diphenyl-5,7 hydroxy-5 trimethyl-2,2,4 heptene-6 one-3 
• 36677-30-2 (+/-)-anti-1-hydroxy-2,4,4-trimethyl-1-phenylpentan-3-one 
• 106596-69-4 2,4,4-trimethyl-1-phenylpentane-1,3-dione 

Relevant academic research and scientific papers

Sml2-promoted reformatsky-type coupling reactions in exceptionally hindered contexts

Highly substituted, very hindered enones were synthesized using a two-step procedure that utilizes a diiodosamarium-promoted Reformatsky-type coupling and dehydration using Martin sulfurane. Both α-chloro- and α-bromoketones were coupled with a variety of carbonyl nucleophiles to form the intermediate β-hydroxyketones, occurring with excellent diastereoselectivity, favoring the syn isomer (R1 = Me). This technique complements other methods and enables the preparation of enones outside of the scope of current olefination methodology.

A CONVENIENT SYNTHESIS OF α-BROMOKETONES FROM OLEFINS

α-Bromoketones are prepared in good yields by the reaction of olefins with sodium bromite in aqueous acetic acid at room temperature.