32279-83-7Relevant academic research and scientific papers
SYNTHESIS OF 2-SUBSTITUTED 3(2H)-ISOTHIAZOLONES FROM 2-SUBSTITUTED 5-AROYL-3(2H)-ISOTHIAZOLONES
Tsolomitis, Athanase,Sandris, Constantine
, p. 569 - 575 (2007/10/02)
2-Substituted 3(2H)-isothiazolones 3 have been prepared from 2-substituted 5-aroyl-3(2H)-isothiazolones 6, which are readily available from N-substituted 3-aroylpropionamides 5.The nucleophilic displacement on the 5-aroyl group was found to proceed easily and quantitatively when a benzene solution of compound 6 was stirred at room temperature either with 10percent sodium hydroxide solution or with solid sodium hydroxide.
The Rearrangement of 2-Benzyl-5-mesitoyl-3(2H)-isothiazolone to 2-Phenyl-6-mesitoyl-3,4-dihydro-1,3-thiazin-4(2H)-one
Tsolomitis, A.,Sandris, C.
, p. 1635 - 1637 (2007/10/02)
2-Benzyl-5-mesitoyl-3(2H)isothiazolone (8) has been prepared from 3-mesitoylpropionic acid (5).Reaction of the isothiazolone 8 with sodium ethoxide in ethanol has been found to yield an isomeric rearranged compound, which was chracterized as 2-phenyl-6-me
Formation of 5-Aroyl-3-(2H)isothiazolones from the Reaction of 3-Aroylpropionamides with Thionyl Chloride (1)
Tsolomitis, A.,Sandris, C.
, p. 1645 - 1646 (2007/10/02)
Reaction of N-substitued-3-aroylpropionamides with excess thionyl chloride was found to give sulfurnitrogen heterocyclic compounds, which were characterized as 2-substituted-5-aroyl-3-(2H)isothiazolones.
