7510-08-9

Upstream product

• 100-46-9 benzylamine 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 122-78-1 phenylacetaldehyde 
• 2243-53-0 styrylacetic acid 
• 13304-62-6 N-benzylacrylamide 
• 98-88-4 benzoyl chloride 
• 2051-95-8 succinylbenzene 
• 100-47-0 benzonitrile 
• 62050-98-0 N-benzyl-4-hydroxy-4-phenylbutanamide 
• 170805-75-1 N-benzyl-4-hydroxy-4-phenyl-2-butynamide 
• 87605-11-6 propynoic acid benzylamide 
• 100-52-7 benzaldehyde 
• 170805-89-7 (Z)-4-Hydroxy-4-phenyl-but-2-enoic acid benzylamide 

Downstream Products

• 93-89-0 benzoic acid ethyl ester 
• 27053-28-7 2,4-Bis(N-benzylcarboxamido)methylene-1,3-dithiethane 
• 62050-98-0 N-benzyl-4-hydroxy-4-phenylbutanamide 
• 215391-92-7 4-(benzylamino)-1-phenylbutan-1-ol 
• 134415-17-1 5-phenyl-1-(phenylmethyl)-2-pyrrolidinone 
• 339566-79-9 C₁₇H₁₅NO₂ 
• 879217-87-5 N-benzyl 3-benzoyl-3-bromopropionamide 

Relevant academic research and scientific papers

Rhodium(ii)-catalysed generation of cycloprop-1-en-1-yl ketones and their rearrangement to 5-aryl-2-siloxyfurans

Donor-acceptor cyclopropenes formed from enoldiazoketones undergo catalytic rearrangement to 5-aryl-2-siloxyfurans via a novel mechanism that involves a nucleophilic addition of the carbonyl oxygen to the rhodium-activated cyclopropene.

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides

A facile visible-light photocatalytic conjugate addition to prepare 1,4-dicarbonyl compounds has been developed by employing readily available aroyl chlorides as aryl radical sources. This operationally simple method shows a broad scope with regard to both aroyl chlorides and Michael acceptors. As a result, a variety of 1,4-diketones were efficiently synthesized in moderate to good yields.

Palladium-catalyzed selective hydrogenolysis of N-alkyl(aryl)-substituted γ-keto amides as an approach to γ-lactams or linear amides

A palladium-catalyzed hydrogenolysis of N-substituted γ-keto amides can proceed with participation of tautomeric 5-hydroxypyrrolidin-2-ones and give either pyrrolidin-2-ones, or linear amides, or their mixtures, depending on the substrate structure.

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11β-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11β-HSD1 over 11β-HSD2 and possess good cellular potency in human and murine 11β-HSD1 assays. A range of in vitro stabilities are observed in human liver microsome assays.

Cobalt-catalyzed regioselective synthesis of pyrrolidinone derivatives by reductive coupling of nitriles and acrylamides

(Chemical Equation Presented) A convenient and highly regioselective method for the synthesis of 5-methylenepyrrolidinone derivatives from various nitriles and acrylamides via a cobalt-catalyzed reductive coupling reaction is described. A possible mechani

Condensation of 4-aryl-4-oxobutanoic acids with benzylamines: Synthetic and structural studies on 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-2-pyrrolones

The microwave-mediated reaction of 4-aryl-4-oxobutanoic acids with benzylamines furnished 1-arylmethyl-3-[(E)-1-arylmethylidene]-5-phenyl-2,3- dihydro-1H-pyrrolones. This result is in contract to the earlier report on this reaction conducted under neat conditions. Structures for the products were assigned on the basis of spectral data and confirmed by independent synthesis.

Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides

A simple and efficient method is described for the synthesis of new functionalized 2-aminothiazoles, the 2-aminothiazole-4-phenyl-5-acetamides 5, in 67-96% yields based on an application of the Hantzsch synthesis. The method involves the reaction of thiou

Rearrangement of 5-benzoyl-3(2H)-isothiazol-3-ones to 6-benzoyl 2,3-dihydro-1,3-thiazin-4(2H)-ones

5-Benzoyl-3(2H)-isothiazol-3-ones 4 were converted to the corresponding isomeric 6-benzoyl-2-substituted-2,3-dihydro-1,3-thiazin-4(2H)-ones 13 by the following reaction sequence: the preparation of aroylpropionamides (3), the conversion of (3) to aroyliso