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4-Dimethylamino-1-methoxy-tetrafluor-benzol, also known as 4-dimethylaminomethyloxy-1,2,3,5-tetrafluorobenzene, is an organic compound with the chemical formula C8H8F4NO. It is a colorless to pale yellow liquid and is characterized by its tetrafluorobenzene core, with a dimethylamino group at the 4-position and a methoxy group at the 1-position. 4-Dimethylamino-1-methoxy-tetrafluor-benzol is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly those containing fluorinated aromatic rings, due to its unique electronic and steric properties. The presence of fluorine atoms can significantly influence the reactivity, lipophilicity, and metabolic stability of the final products, making 4-Dimethylamino-1-methoxy-tetrafluor-benzol a valuable building block in the development of new drugs and pesticides.

3228-12-4

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3228-12-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3228-12-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,2 and 8 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3228-12:
(6*3)+(5*2)+(4*2)+(3*8)+(2*1)+(1*2)=64
64 % 10 = 4
So 3228-12-4 is a valid CAS Registry Number.

3228-12-4Downstream Products

3228-12-4Relevant academic research and scientific papers

Synthesis method of 1, 4-dimethoxy tetrafluorobenzene

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Paragraph 0010; 0031; 0035; 0038, (2021/07/11)

The invention discloses a synthesis method of 1, 4-dimethoxy tetrafluorobenzene, the synthesis method comprises the following steps: (1) reacting N, N-dimethyl pentafluoroaniline with sodium methoxide to obtain an intermediate I; (2) mixing the intermediate I with a first organic solvent, and then reacting with methyl trifluoromethanesulfonate to obtain an intermediate II; and (3) mixing the intermediate II with a second organic solvent, and reacting with methanol in alkali and protective gas atmosphere to obtain the 1, 4-dimethoxy tetrafluorobenzene. The synthesis method of the 1, 4-dimethoxy tetrafluorobenzene has the advantages of mild reaction conditions, no need of harsh conditions, high controllability, simple post-treatment, easiness in operation, capability of effectively improving the overcharge resistance of the lithium ion battery and the like.

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