3228-14-6

Upstream product

• 10268-58-3 4-bromo-N,N-dimethyl-2,3,5,6-tetrafluoroaniline 
• 344-07-0 1-chloro-2,3,4,5,6-pentafluorobenzene 
• 344-04-7 bromopentafluorobenzene 
• 4920-56-3 2.3.5.6-Tetrafluor-N-methyl-anilin 
• 74-88-4 methyl iodide 
• 110-91-8 morpholine 
• 1801-14-5 1-(N,N-dimethylamine)pentafluorobenzene 
• 10269-03-1 4-chloro-1-(N,N-dimethylamine)tetrafluorobenzene 
• 827-15-6 1,2,3,4,5-pentafluoro-6-iodobenzene 
• 67-56-1 methanol 

Downstream Products

• 1415155-85-9 C₁₆H₁₂F₈N₂Se₂ 

Relevant academic research and scientific papers

Addition of Carbon-Fluorine Bonds to a Mg(I)-Mg(I) Bond: An Equivalent of Grignard Formation in Solution

Addition of the carbon-fluorine bond of a series of perfluorinated and polyfluorinated arenes across the Mg-Mg bond of a simple coordination complex proceeds rapidly in solution. The reaction results in the formation of a new carbon-magnesium bond and a new fluorine-magnesium bond and is analogous to Grignard formation in homogeneous solution.

Synthesis of potassium 4-(1-azol-1-yl)-2,3,5,6- tetrafluorophenyltrifluoroborates from K[C6F5BF 3] and alkali metal azol-1-ides. the dramatic distinction in nucleophilicity of alkali metal azol-1-ides and dialkylamides

Nucleophilic substitution of fluorine atom in K[C6F 5BF3] with alkali metal azol-1-ides in polar aprotic solvent (DMF, DMSO) at 60-130 C gives potassium 4-(azol-1-yl)-2,3,5,6- tetrafluorophenyltrifluoroborates, K[4-AzC6F4BF 3] (AzH = pyrrole, pyrazole, imidazole, indole, and benzimidazole). Unexpectedly, diethylamine and morpholine do not react with K[C 6F5BF3] under the same conditions while pentafluorobenzene and R2NC6F4H form at 150 C. Reaction of K[C6F5BF3] with Na[NR2] in diglyme or DMSO proceeds similar way. The assumed reason is the relatively low nucleophilicity of both secondary amines and alkali metal dialkylamides which results in destructive by-reaction with K[C6F 5BF3] rather than in its aminodefluorination. This is confirmed by the competitive nucleophilic aminodefluorination of a model substrate, C6F5Ph, with sodium indolide/sodium morpholinide.

An aromatic glaser-hay reaction

(Chemical Equation Presented) A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are react