32291-85-3

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 2788-86-5 4-Chlorostyrene oxide 
• 873-55-2 sodium benzenesulfonate 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 1073-67-2 4-vinylbenzyl chloride 
• 126613-18-1 1-(benzenesulfonyl)-2-(p-chlorophenyl)acetylene 
• 873-73-4 4-n-chlorophenylacetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 108-98-5 thiophenol 

Downstream Products

• 66022-86-4 [2-Benzenesulfonyl-1-(4-chloro-phenyl)-ethyl]-dimethyl-amine 
• 911832-91-2 methyl 4-phenylsulfonyl-3-(4-chlorophenyl)butyrate 
• 89130-31-4 (Z)-1-chloro-4-(3-methylbut-1-en-1-yl)benzene 
• 1363721-85-0 C₂₈H₂₄ClFO₃S₂ 
• 1363721-95-2 C₂₈H₂₄ClFO₃S₂ 

Relevant academic research and scientific papers

Visible-Light-Mediated Alkenylation of Alkyl Boronic Acids without an External Lewis Base as an Activator

Herein we report a protocol for the direct visible-light-mediated alkenylation of alkyl boronic acids at room temperature without an external Lewis base as an activator, and we propose a mechanism involving benzenesulfinate activation of the alkyl boronic acids. The protocol permits the efficient functionalization of a broad range of cyclic and acyclic primary and secondary alkyl boronic acids with various alkenyl sulfones. We demonstrated its utility by preparing or functionalizing several pharmaceuticals and natural products.

Visible-light-mediated alkylation of 4-alkyl-1,4-dihydropyridines with alkenyl sulfones

Herein we report a mild, general protocol for visible-light-mediated alkylation of 4-alkyl-1,4-dihydropyridines with alkenyl sulfones. The protocol permits efficient functionalization of sulfones with a broad range of cyclic and acyclic secondary and tert

Stereoselective Synthesis of Z-α,β-Unsaturated Sulfones Using Peterson Reagents

New Peterson reagents were prepared by introducing alkyloxy groups on the silicon atom in order to fix the conformation of the sulfone anion. The reagents 1d and 1e reacted with a variety of aldehydes after the treatment with Li-base to give Z-α,β-unsaturated sulfones with up to >99:1 selectivity in good to excellent yields. For the reaction with aliphatic aldehydes, CPME (cyclopentyl methyl ether) is the choice of solvent, while DME (1,2-dimethoxyethane) gave higher selectivity for the reaction with aromatic aldehydes.

Metal and solvent free selective oxidation of sulfides to sulfone using bifunctional ionic liquid [pmim]IO4

The oxidation of organo-sulfides to sulfones has been accomplished using an easily accessible bifunctional ionic liquid, [pmim]IO4 in the absence of any other oxidants, metal and organic solvent at ambient temperature. A variety of sulfides including dialkyl, aryl-alkyl, diaryl, and aryl-hetero aryl have been oxidized to the corresponding functionalized sulfones in high yields by this procedure.

A one-pot regioselective synthetic route to vinyl sulfones from terminal epoxides in aqueous media

A highly efficient LiBr catalysed regioselective synthesis of vinyl sulfones from readily available terminal epoxides and sodium sulfinates in a one-pot procedure using water as a reaction medium is reported. The protocol is adorned with several attributes of green chemistry like recycling of the catalyst, atom-economy and an aqueous medium.

Studies on hydrozirconation of 1-alkynyl sulfoxides or sulfones and the application for the synthesis of stereodefined vinyl sulfoxides or sulfones

The hydrozirconation reaction of 1-alkynyl sulfoxides or sulfones with CP2Zr(H)Cl in THF at room temperature predominantly gave Z-β-zirconated vinyl sulfoxides or sulfones with excellent regioselectivity. Compared with 1-alkynyl sulfoxides, the hydrozirconation reaction of 1-alkynyl sulfones exhibits great synthetic potential, leading to the efficient preparation of Z-β-halovinyl sulfones, Z-β-sulfonyl α,β-unsaturated ketones, and Z-β-alkynyl vinyl sulfones. Although the reaction mechanisms are still not clear, the neighboring group participation of the sulfinyl or sulfonyl group may be playing an important role in this unique hydrozirconation reaction.