32293-02-0Relevant academic research and scientific papers
Oligosaccharide synthesis in microreactors
Carrel, Frederic R.,Geyer, Karolin,Codee, Jeroen D. C.,Seeberger, Peter H.
, p. 2285 - 2288 (2008/02/05)
Described is the combination of microreactors and fluorous phase chemistry to assemble oligosaccharides. The synthesis of a β-(1→6) linked D-glucopyranoside homotetramer serves to illustrate this approach. Glycosylations employing a Fmoc-protected glucosy
Synthesis of enantiopure ω-functionalized C15 α-amino carboxylates
Markidis, Theodoros,Kokotos, George
, p. 1685 - 1688 (2007/10/03)
An efficient route for the synthesis of enantiopure ω-hydroxy, ω-carboxy, ω-oxo, and ω-amino α-amino acids and bis-α-amino acids was developed. The synthesis of ω-trityloxy δ,ε-unsaturated α-amino acids was based on the Wittig reaction of methyl (2S)-2-[bis(tert-butoxycarbonyl)-amino]-5-oxopentanoate with ω-trityloxy alkylidene triphenylphosphoranes. After hydrogenation, the ω-hydroxy α-amino acid was used as starting material for the synthesis of other ω-functionalized α-amino acids. The length of the side chain of α-amino acids or bis-α-amino acids depends on the starting alkanediol or dibromide used to prepare the phosphoranes.
