3230-49-7

Upstream product

• 100-52-7 benzaldehyde 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 100-46-9 benzylamine 

Downstream Products

• 891-43-0 5-nitro-2-phenylbenzo[d]oxazole 
• 77434-64-1 methyl (4-benzyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetate 
• 118383-49-6 2-Imino-5-(2-phenyl-benzooxazol-5-ylmethyl)-thiazolidin-4-one 
• 118383-48-5 methyl 3-(2-phenylbenzoxazol-5-yl)-2-chloropropionate 
• 41373-37-9 5-amino-2-phenyl-1,3-benzoxazole 

Relevant academic research and scientific papers

O-Hydroxyaniline Schiff base derivative and preparation method thereof

The invention discloses an o-hydroxyaniline Schiff base derivative and a preparation method thereof. The structural formula of the Schiff base derivative is as shown in specification. The preparationmethod comprises the following steps: reacting 2-amino-4

Synthesis, characterization and Pd(II)-coordination chemistry of the ligand tris(quinolin-8-yl)phosphite. Application in the catalytic aerobic oxidation of amines

The synthesis and characterization of the ligand tris(quinolin-8-yl)phosphite, (P(Oquin)3), are described and its coordination chemistry toward the metal precursor [Pd(COD)Cl2] (COD = 1,5-cyclooctadiene, C8H12) is reported. A new Pd(ii)-P(Oquin)3 metal complex was isolated and fully characterized ([Pd{P(Oquin)3}Cl2]), and its X-ray diffraction analysis shows that the phosphite ligand coordinates as a bidentate P-N chelate. This complex is an efficient catalyst for the solvent-free mild oxidative coupling of primary amines to imines using air as an oxidant, obtaining moderate to good yields (up to 99%) and turnover numbers (TONs up to 230). This catalyst can be recovered from the reaction mixture and reused in a subsequent run without a significant loss of activity. Kinetic measurements of the oxidation of benzylamine suggest that the rate law is r = kapp[BnNH2][cat] ([BnNH2] = molar concentration of benzylamine, [cat] = molar concentration of [Pd{P(Oquin)3}Cl2], kapp = k[O2]c = 0.756 L mol-1 h-1 = apparent rate constant). In situ NMR tests were performed to gain some insight into the reactivity of the Pd(ii)-P(Oquin)3 complex toward benzylamine.

Selective alkylation of aminophenols

O-or N-Alkylated derivatives of aminophenols are important synthetic intermediates in organic synthesis. A series of aminophenols were selectively alkylated on their hydroxyl group in good yields via benzaldehyde protection of the amino group, subsequent alkylation, and hydrolysis; or on their amino group via imination and following reduction. ARKAT USA, Inc.

Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships

A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2,4-thiazolidinediones was also established using aminophenol 2,4- thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.