Welcome to LookChem.com Sign In|Join Free

CAS

  • or

323176-93-8

Post Buying Request

323176-93-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 98% HPLC Ethyl α-(p-Methoxyphenyl)-β-(diMethylaMino)propionate;α-[(DiMethylaMino)Methyl]-4-Methoxybenzeneacetic Acid Ethyl Ester CAS:323176-93-8 CAS NO.323176-93-8

    Cas No: 323176-93-8

  • USD $ 7.0-8.0 / Metric Ton

  • 1 Metric Ton

  • 1000 Metric Ton/Day

  • KAISA GROUP INC
  • Contact Supplier

323176-93-8 Usage

Description

Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate, also known as Venlafaxine EP Impurity B, is an organic compound that is an impurity found in Venlafaxine, a widely prescribed antidepressant medication. It is characterized by its unique chemical structure, which includes a p-methoxyphenyl group and a dimethylamino group attached to a propionate backbone.

Uses

Used in Pharmaceutical Industry:
Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate is used as an impurity in Venlafaxine for [application reason]. It is important to monitor and control the levels of this impurity in Venlafaxine to ensure the safety and efficacy of the medication. The presence of impurities can affect the quality, stability, and performance of the drug, so their identification and management are crucial in the pharmaceutical manufacturing process.

Synthesis

A mixture of ethyl p-methoxyphenylacetate (4 g, 20.62 mmol), paraformaldehyde (1.05 g, 35.0 mmol) and TBAI (0.381 g, 1.03 mmol) was heated in PhMe (16 ml) at 80-85 oC for 3.5 hours. The reaction mixture was allowed to cool. Then, a solution of Me2NH in THF was added to the reaction mixture at 0 oC in the presence of catalytic FeCl3 (0.160 g, 0.001 mol) and stirred for 45 minutes. After completion of the reaction, 100 ml water was added to the reaction mixture and aqueous layer was acidified with conc. HCl (pH = 2). Aqueous layer was washed with DCM (3x 50 ml) and made alkaline (pH = 8) using 5% NaOH solution, extracted with DCM (3x 50 ml), washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Column chromatographic purification over silca gel (0.5% MeOH in CHCl3) furnished aminoester 65 as a thick colourless oil (3.08 g).?When the reaction was carried out without catalyst, it took 48 hours for completetion.

Check Digit Verification of cas no

The CAS Registry Mumber 323176-93-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,3,1,7 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 323176-93:
(8*3)+(7*2)+(6*3)+(5*1)+(4*7)+(3*6)+(2*9)+(1*3)=128
128 % 10 = 8
So 323176-93-8 is a valid CAS Registry Number.

323176-93-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate

1.2 Other means of identification

Product number -
Other names UNII-20A3002JTT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:323176-93-8 SDS

323176-93-8Relevant articles and documents

Practical synthesis of (±)-venlafaxine

Chavan, Subhash P.,Khobragade, Dushant A.,Thakkar, Mahesh,Kalkote, Uttam R.

, p. 3901 - 3906 (2007)

A practical total synthesis of antidepressant (±)-venlafaxine is disclosed. Copyright Taylor & Francis Group, LLC.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 323176-93-8