323187-56-0

Basic information

• Product Name: N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide
• Synonyms: N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide
• CAS NO: 323187-56-0
• Molecular Weight: 324.467
• Mol File: 323187-56-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide(323187-56-0)
• EPA Substance Registry System: N¹,N³-bis((1R,2R)-2-aminocyclohexyl)-2,2-dimethylmalonamide(323187-56-0)

Safety Data

• Hazardous Substances Data: 323187-56-0(Hazardous Substances Data)

Upstream product

• 5659-93-8 2,2-Dimethylmalonyl chloride 
• 146504-07-6 tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 323187-46-8 C₂₇H₄₈N₄O₆ 

Downstream Products

• 323187-52-6 2,2-Dimethyl-N,N'-bis-((1R,2R)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclohexyl)-malonamide 

Relevant articles and documents

Au(III) complexes with tetradentate-cyclam-based ligands

Chiral cyclam (1,4,8,11-tetraazacyclotetradecane) derivatives were synthesized stepwise from chiral mono-Boc-1,2-diamines and (dialkyl)malonyl dichloride via open diamide-bis(N-Boc-amino) intermediates (65-91%). Deprotection and ring closure with a second malonyl unit afforded the cyclam tetraamide precursors (80-95%). The new protocol allowed the preparation of the target cyclam derivatives (53-59%) by a final optimized hydride reduction. Both the open tetraamine intermediates and the cyclam derivatives successfully coordinated with AuCl3 to give moderate to excellent yields (50-96%) of the corresponding novel tetra-coordinated N,N,N,N-Au(III) complexes with alternating five- and six-membered chelate rings. The testing of the catalytic ability of the cyclam-based N,N,N,N-Au(III) complexes demonstrated high catalytic activity of some complexes in selected test reactions (full conversion in 1-24 h, 62-97% product yields).