323191-91-9Relevant academic research and scientific papers
Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
Kotharé, Mohit A.,Ohkanda, Junko,Lockman, Jeffrey W.,Qian, Yimin,Blaskovich, Michelle A.,Sebti, Said M.,Hamilton, Andrew D.
, p. 9833 - 9841 (2007/10/03)
This paper describes the development of a novel terphenyl-based tripeptide mimetic of the CAAX carboxy terminal sequence of Ras. We employ a concise synthesis to form a series of differently functionalized terphenyl inhibitors of protein farnesyltransfera
