1265883-89-3

Upstream product

• 1265882-90-3 (1R,2R,4R)-4-hydroxy-cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 
• 1265882-89-0 (1R,2R,5R)-7-oxo-6-oxabicyclo[3,2,1]octane-2-carboxylic acid methyl ester 
• 1265882-88-9 (1R,2R,4R,5S)-4-iodo-7-oxo-6-oxabicyclo[3.2.1]-octane-2-carboxylic acid methyl ester 
• 323196-38-9 (1R,2R)-cyclohex-4-ene 1,2-dicarboxylic acid monomethyl ester 
• 1265883-87-1 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester 1-methyl ester 
• 1265883-86-0 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 1-methyl ester 
• 1265883-85-9 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-benzyl ester 1-methyl ester 
• 1108656-90-1 N-methylhex-5-en-1-amine tosylate salt 
• 1265883-88-2 (1R,2R,4R)-4-(tert-butyldiphenylsilanyloxy)cyclohexane-1,2-dicarboxylic acid 2-tert-butyl ester 
• 922520-05-6 2,2,2-trifluoro-N-(hex-5-enyl)-N-methylacetamide 
• 2695-47-8 6-Bromo-1-hexene 
• 31139-02-3 (1R,6S)-6-methoxycarbonyl-3-cyclohexene-1-carboxylic acid 

Downstream Products

• 1265883-90-6 (1R,2R,4R)-5-(tert-butyldiphenylsilanyloxy)-2-(hex-5-enyl-methylcarbamoyl)cyclohexanecarboxylic acid 
• 1265883-91-7 (1R,2S)-methyl 1-((1R,2R,5R)-5-(tert-butyldiphenylsilyloxy)-2-(hex-5-enyl(methyl)carbamoyl)cyclohexanecarboxamido)-2-vinylcyclopropanecarboxylate 

Relevant academic research and scientific papers

Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, and pharmaceutical compositions and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula (Ia) or (Ib), pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.