323204-63-3

Basic information

• Product Name: acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester
• Synonyms: acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester
• CAS NO: 323204-63-3
• Molecular Weight: 231.251
• Mol File: 323204-63-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester(323204-63-3)
• EPA Substance Registry System: acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester(323204-63-3)

Safety Data

• Hazardous Substances Data: 323204-63-3(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 323204-69-9 1-benzyl-5-hydroxy-1,5-dihydro-2H-pyrrol-2-one 

Downstream Products

• 323204-65-5 (R)-1-Benzyl-5-hydroxy-1,5-dihydro-pyrrol-2-one 
• 323204-67-7 acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester 
• 323204-73-5 acetic acid 1-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester 

Relevant articles and documents

Chemoenzymatic total synthesis and determination of the absolute configuration of (S)-nebracetam

We have developed an asymmetric total synthesis of nebracetam 3 by a chemoenzymatic strategy. Diastereoselective Michael addition of nitromethane to the chiral lactam (S)-9d (>99% ee), which was prepared by lipase-catalyzed kinetic resolution, afforded the Michael product 10d in 99% yield with 86% de. Chemical transformations of 10d including recrystallization furnished the chiral nebracetam 3 and its derivative. The absolute configuration of the chiral (-)-nebracetam was determined to be an (S)-configuration.