323205-01-2

Upstream product

• 323205-00-1 [(2R,4R)-2-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-acetic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 323204-99-5 (2R,4R)-2-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidine 
• 323204-98-4 2-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 323204-96-2 tert-butyl (2R,4R)-4-[(tert-butyldiphenylsilyl)oxy]-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 323204-95-1 1-(tert-butyl) 2-methyl (2R,4R)-4-((tert-butyldiphenylsilyl)oxy)pyrrolidine-1,2-dicarboxylate 
• 323204-97-3 4-(tert-butyl-diphenyl-silanyloxy)-2-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 2584-71-6 cis-hydroxy-D-proline 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 323205-03-4 [(2R,4R)-2-(tert-Butoxycarbonylamino-methyl)-4-(toluene-4-sulfonyloxy)-pyrrolidin-1-yl]-acetic acid methyl ester 
• 323205-04-5 [(2R,4S)-4-(6-Benzyloxycarbonylamino-purin-9-yl)-2-(tert-butoxycarbonylamino-methyl)-pyrrolidin-1-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Pyrrolidine PNA: A Novel Conformationally Restricted PNA Analogue

A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.