32327-57-4

Basic information

• Product Name: 4-[(4-Hydroxybenzylidene)amino]benzoic acid ethyl ester
• Synonyms: 4-[(4-Hydroxybenzylidene)amino]benzoic acid ethyl ester;(E)-ethyl 4-((4-hydroxybenzylidene)amino)benzoate
• CAS NO: 32327-57-4
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.2952
• Mol File: 32327-57-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 430.2°Cat760mmHg
• Flash Point: 214°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 1.32E-07mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 4-[(4-Hydroxybenzylidene)amino]benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-Hydroxybenzylidene)amino]benzoic acid ethyl ester(32327-57-4)
• EPA Substance Registry System: 4-[(4-Hydroxybenzylidene)amino]benzoic acid ethyl ester(32327-57-4)

Safety Data

• Hazardous Substances Data: 32327-57-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H15NO3/c1-2-20-16(19)13-5-7-14(8-6-13)17-11-12-3-9-15(18)10-4-12/h3-11,17H,2H2,1H3

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 80337-07-1 bis[1-(2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)]-4-hydroxyphenylmethane 

Relevant articles and documents

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.