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Sulfuric acid, mono(4-methylphenyl) ester, also known as p-toluenesulfonic acid, is an organic compound with the chemical formula C8H10O3S. It is a colorless, viscous liquid that is soluble in water and other organic solvents. Sulfuric acid, mono(4-methylphenyl) ester is known for its strong acidic nature, which makes it a versatile catalyst in various chemical reactions.

3233-58-7

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3233-58-7 Usage

Uses

Used in Organic Synthesis:
Sulfuric acid, mono(4-methylphenyl) ester is used as a catalyst in organic synthesis for its ability to facilitate a wide range of chemical reactions, including esterification, hydrolysis, and condensation reactions. Its strong acidic properties enable it to act as an effective catalyst, improving the efficiency and selectivity of the reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, sulfuric acid, mono(4-methylphenyl) ester is used as a reagent in the manufacture of various drugs. Its acidic nature allows it to participate in the synthesis of active pharmaceutical ingredients, contributing to the development of new medications.
Used in Dye Production:
Sulfuric acid, mono(4-methylphenyl) ester is utilized in the production of dyes due to its ability to act as a catalyst in dye synthesis. Its strong acidity aids in the formation of dye molecules, enhancing the color intensity and stability of the final product.
Used in Pesticide Manufacturing:
In the agricultural sector, sulfuric acid, mono(4-methylphenyl) ester is employed in the manufacturing process of pesticides. Its acidic properties play a crucial role in the synthesis of active ingredients, ensuring the effectiveness of these products in controlling pests and diseases.
Used in Plastics, Resins, and Polymers Production:
Sulfuric acid, mono(4-methylphenyl) ester is also used in the production of plastics, resins, and polymers. Its strong acidic nature aids in the polymerization process, contributing to the formation of polymer chains and the development of various plastic materials with specific properties.
Due to the strong acidic nature of sulfuric acid, mono(4-methylphenyl) ester, it is essential to handle and use it with care, following proper safety precautions to prevent any potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 3233-58-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,2,3 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3233-58:
(6*3)+(5*2)+(4*3)+(3*3)+(2*5)+(1*8)=67
67 % 10 = 7
So 3233-58-7 is a valid CAS Registry Number.

3233-58-7Synthetic route

p-cresol
106-44-5

p-cresol

trimethyl-sulfo-ammonium betaine
63147-26-2

trimethyl-sulfo-ammonium betaine

p-cresol sulfate
3233-58-7

p-cresol sulfate

Conditions
ConditionsYield
With sodium carbonate
p-cresol
106-44-5

p-cresol

p-cresol sulfate
3233-58-7

p-cresol sulfate

Conditions
ConditionsYield
With chlorosulphuric acid; chloroform at -10℃;
With quinoline; chlorosulphuric acid at 0℃;
With pyridine; chlorosulphuric acid at 0℃;
With pyridine; chlorosulfonic acid
With chlorosulfonic acid In dichloromethane
potassium p-cresolate
1192-96-7

potassium p-cresolate

p-cresol sulfate
3233-58-7

p-cresol sulfate

Conditions
ConditionsYield
With potassium pyrosulfate
pyridine
110-86-1

pyridine

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-cresol
106-44-5

p-cresol

p-cresol sulfate
3233-58-7

p-cresol sulfate

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-cresol
106-44-5

p-cresol

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

p-cresol sulfate
3233-58-7

p-cresol sulfate

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

p-cresol
106-44-5

p-cresol

chloroform
67-66-3

chloroform

A

p-cresol sulfate
3233-58-7

p-cresol sulfate

B

4-hydroxy-toluene-2-sulfonic acid
102014-39-1

4-hydroxy-toluene-2-sulfonic acid

Conditions
ConditionsYield
at -10℃;
p-cresol
106-44-5

p-cresol

anhydro-pyridinesulfuric acid

anhydro-pyridinesulfuric acid

p-cresol sulfate
3233-58-7

p-cresol sulfate

Conditions
ConditionsYield
With chloroform
p-cresol sulfate
3233-58-7

p-cresol sulfate

p-cresol
106-44-5

p-cresol

Conditions
ConditionsYield
With Taka-diastase
With 1,3-Dimethoxybenzene In 1,4-dioxane-d8 at 17℃; Rate constant;
With Helix pomatia arylsulfatase In aq. acetate buffer at 21℃; for 4h; Catalytic behavior; Enzymatic reaction;
With arylsulfatase from Helix pomatia In aq. acetate buffer at 21℃; for 24h; pH=7; Kinetics; Enzymatic reaction;
p-cresol sulfate
3233-58-7

p-cresol sulfate

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

Conditions
ConditionsYield
With potassium permanganate Verseifung des Produktes mit Salzsaeure;
p-cresol sulfate
3233-58-7

p-cresol sulfate

4-hydroxy-toluene-3-sulfonic acid
7134-06-7

4-hydroxy-toluene-3-sulfonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,3-dimethoxybenzene / dioxane-d8 / 17 °C
2: SO3 / nitromethane / 0.5 h / 0 °C
View Scheme
diethyl 2-(3-bromo-2-chloro-4,5-difluorobenzoyl)malonate
112062-52-9

diethyl 2-(3-bromo-2-chloro-4,5-difluorobenzoyl)malonate

p-cresol sulfate
3233-58-7

p-cresol sulfate

ethyl 2-(3-bromo-2-chloro-4,5-difluorobenzoyl)acetate
112062-53-0

ethyl 2-(3-bromo-2-chloro-4,5-difluorobenzoyl)acetate

Conditions
ConditionsYield
In water

3233-58-7Relevant academic research and scientific papers

Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge

Cho, Joo-Youn,Matsubara, Tsutomu,Kang, Dong Wook,Ahn, Sung-Hoon,Krausz, Kristopher W.,Idle, Jeffrey R.,Luecke, Hans,Gonzalez, Frank J.

, p. 1063 - 1074 (2010)

Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed cholic acid, an FXR ligand, using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry (TOFMS). Multivariate data analysis between wild-type and Fxr-null mice on a cholic acid diet revealed that the most increased ions were metabolites of p-cresol (4-methylphenol), corticosterone, and cholic acid in Fxr-null mice. The structural identities of the above metabolites were confirmed by chemical synthesis and by comparing retention time (RT) and/or tandem mass fragmentation patterns of the urinary metabolites with the authentic standards. Tauro-3α,6,7α,12α-tetrol (3α,6,7α,12α- tetrahydroxy-5β-cholestan-26-oyltaurine), one of the most increased metabolites in Fxr-null mice on a CA diet, is a marker for efficient hydroxylation of toxic bile acids possibly through induction of Cyp3a11. A cholestatic model induced by lithocholic acid revealed that enhanced expression of Cyp3a11 is the major defense mechanism to detoxify cholestatic bile acids in Fxr-null mice. These results will be useful for identification of biomarkers for cholestasis and for determination of adaptive molecular mechanisms in cholestasis.

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