313266-11-4Relevant academic research and scientific papers
Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones
Wu, Wenbin,Yuan, Xiaoqian,Hu, Juan,Wu, Xinxin,Wei, Yuan,Liu, Zunwu,Lu, Junzhu,Ye, Jinxing
supporting information, p. 4524 - 4527 (2013/09/24)
The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly prac
Access to α-functionalized glycine derivatives with arylboronic acid via imino amides
Zhao, Liang,Liao, Xiaohong,Li, Chao-Jun
scheme or table, p. 2953 - 2956 (2010/01/21)
An efficient approach was developed for the α-arylation of imino amides with arylboronic acids. Different substrates were examined for this arylation reaction. For the α-arylation of N-phenylimino amide, due to the electron-withdrawing properties of the phenyl group, the tautomerization between the amide and the iminol is more difficult. Thus, low reaction rate and low conversion were observed. This phenomenon supported our previously proposed mechanism for the arylation of -amino acid derivatives. Meanwhile, this method provides an alternative approach for the synthesis of α-functionalized glycine derivatives. Georg Thieme Verlag Stuttgart.
Amino amides, peptides and peptidomimetics
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Page 14, (2010/02/05)
Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.
