32333-53-2

Basic information

• Product Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride
• Synonyms: BENZENESULFONYL CHLORIDE, 4-CHLORO-3-(TRIFLUOROMETHYL)-;BUTTPARK 83\07-19;AKOS BBS-00007012;4-CHLORO-3-(TRIFLUOROMETHYL)BENZENESULPHONYL CHLORIDE;4-CHLORO-3-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE;4-Chloro-3-(trifluoromethyl)benzenesulfonyl;4-chloro-3-(trifluoroMethyl)benzene-1-sulfonyl chloride;4-Chlorine-3-(trifluoroMethyl) benzenesulfonyl chloride
• CAS NO: 32333-53-2
• Molecular Formula: C₇H₃Cl₂F₃O₂S
• Molecular Weight: 279.06
• EINECS: 1533716-785-6
• Product Categories: Fluoro-contained benzenesulfonyl chloride series
• Mol File: 32333-53-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 28 °C
• Boiling Point: 83-84°C/0.1mm
• Flash Point: 128.146 °C
• Appearance: /
• Density: 1.627 g/cm³
• Vapor Pressure: 0.00409mmHg at 25°C
• Refractive Index: 1.497
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride(32333-53-2)
• EPA Substance Registry System: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride(32333-53-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39-45-27
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 32333-53-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-(trifluoromethyl)benzenesulfonyl chloride, also known as Tosyl chloride, is a chemical compound with the molecular formula C7H4ClF3O2S. It is a versatile raw material used in organic synthesis, and is commonly employed in the preparation of sulfonyl chlorides, which are important intermediates in pharmaceuticals, agrochemicals, and dyes. Tosyl chloride is a colorless to pale yellow liquid with a pungent odor, and it is highly reactive, making it a valuable reagent for a variety of chemical reactions. It is also used as a reagent for the micro analysis of hydroxyl, amines, and amino acids. Due to its hazardous nature, proper precautions should be taken when handling this compound, including the use of protective equipment and adherence to safe handling procedures.

InChI:InChI=1/C7H3Cl2F3O2S/c8-6-2-1-4(15(9,13)14)3-5(6)7(10,11)12/h1-3H

Upstream product

• 445-13-6 3-chloro-4-(trifluoromethyl)aniline 
• 7446-09-5 sulfur dioxide 

Downstream Products

• 111711-54-7 1-(4-Chloro-3-trifluoromethyl-benzenesulfonyl)-5-ethoxy-pyrrolidin-2-one 
• 899422-52-7 N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-trifluoromethyl-benzenesulfonamide 
• 899424-20-5 3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyrazine-2-carboxylic acid methyl ester 
• 1382801-44-6 Ethyl [4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]methylphosphinate 
• 1382801-49-1 4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide 
• 1382801-56-0 Ethyl (4-chloro-2-(4-chloro-3-(trifluoromethyl)phenylsulfonamido)phenyl)(phenyl)phosphinate 
• 1382801-59-3 [4-Chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]phenylphosphinic acid 
• 1382801-48-0 [4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]methylphosphinic acid 
• 1001326-27-7 4-chloro-3-trifluoromethyl-N-[5-chloro-2-(morpholine-4-carbonyl)-phenyl]benzenesulfonamide 
• 1001326-28-8 4-chloro-3-trifluoromethyl-N-[5-chloro-2-(piperidine-1-carbonyl)-phenyl]benzenesulfonamide 
• 1001326-25-5 4-Chloro-N-[5-chloro-2-(pyridine-4-carbonyl)-phenyl]-3-trifluoromethylbenzenesulfonamide 
• 1100318-71-5 C₁₄H₉ClF₃N₃O₂S 

Relevant articles and documents

Cyclic amine derivatives and methods of use

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ

Compounds of formula (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation mediated by Bradykinin. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes wherein q, t, R, Ra, Rb, Rc and R2 are as defined herein.