32345-57-6Relevant academic research and scientific papers
Highly enantioselective hydrogenation of α-keto esters catalyzed by Ru-tunephos complexes
Wang, Chun-Jiang,Sun, Xianfeng,Zhang, Xumu
, p. 1169 - 1172 (2006)
Various enantiomerically pure α-hydroxy esters were synthesized by asymmetric hydrogenation of α-keto esters catalyzed by Ru-C n-Tunephos complex. Up to 97.1% ee has been achieved for both α-aryl and α-alkyl substituted α-keto esters. Georg Thieme Verlag Stuttgart.
The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation
Guo, Huan,Li, Jing,Liu, Delong,Zhang, Wanbin
, p. 3665 - 3673 (2017/09/11)
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).
Catalytic asymmetric reaction with water: Enantioselective synthesis of α-hydroxyesters by a copper-carbenoid O-H insertion reaction
Zhu, Shou-Fei,Chen, Chao,Cai, Yan,Zhou, Qi-Lin
, p. 932 - 934 (2008/09/20)
(Chemical Equation Presented) Taking on water: A novel catalytic asymmetric metal-carbenoid insertion reaction with water has been developed with copper complexes of chiral spiro bisoxazoline ligands as catalysts. This reaction provides an efficient and practical procedure for preparing chiral α-hydroxyesters and acids starting from readily available materials in high yields and enantioselectivities. BArF- = [B{3,5-(CF3)2C6H3)} 4]-.
Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations
Sun, Xianfeng,Zhou, Le,Li, Wei,Zhang, Xumu
, p. 1143 - 1146 (2008/09/18)
(Chemical Equation Presented) A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Rucatalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantioselective synthesis of β-methyl chiral amines and α-hydroxy acid derivatives, respectively.
Enantioselectivity of carbonic anhydrase catalyzed hydrolysis of mandelic methyl esters
Chenevert, Robert,Letourneau, Martin
, p. 314 - 316 (2007/10/02)
We report the first enantioselective hydrolysis of esters catalyzed by caebonic anhydrase.We found that mandelic methyl esters are good substrates for carbonic anhydrase.The R enantiomers are better substrates and enantiomeric excess values are moderate (40-51percent).
