323580-68-3

Usage

Uses

Used in Pharmaceutical Industry:
1-BOC-6-CHLOROINDOLE is used as a key intermediate in the synthesis of various pharmaceutical compounds. The BOC protecting group allows for selective reactions to occur at other positions on the indole ring, while the chlorine atom at the 6 position can be further modified or serve as a handle for attaching other functional groups.
1-BOC-6-CHLOROINDOLE is used as a building block for the development of new drugs and pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the design and synthesis of biologically active molecules with potential therapeutic applications.
Research into 1-BOC-6-CHLOROINDOLE and its derivatives is ongoing, with the aim of discovering novel compounds with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects. This ongoing research highlights the importance of 1-BOC-6-CHLOROINDOLE as a versatile and promising chemical entity in the field of medicinal chemistry.

InChI:InChI=1/C13H14ClNO2/c1-13(2,3)17-12(16)15-7-6-9-4-5-10(14)8-11(9)15/h4-8H,1-3H3

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 17422-33-2 6-chloroindole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 352359-22-9 {1-[(tert-butoxy)carbonyl]-6-chloro-1H-indol-2-yl}boronic acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- And C3-Borylated Indolines

Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biologically active molecules. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

A kind of aldosterone synthase modulators method for the preparation of intermediates

The invention discloses a method for preparing an aldosterone synthase conditioning agent intermediate. The method comprises the following steps: implementing reaction on a reaction substrate under Boc protection with hydrogen chloride and ethanol for acetal protection, directly heating to remove Boc protection without separation, implementing N-methylation reaction so as to obtain an N-methylation product, and directly removing acetal protection without separation, thereby obtaining a target product. The method is high in route reaction conversion rate and high in product purity, the product quality can be effectively ensured, and workshop production can be achieved.

Palladium catalyzed tandem alkenyl- and aryl-C-N bond formation: A cascade N-annulation route to 4-, 5-, 6- and 7-chloroindoles

A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nucleophile.

2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

The present invention is directed to a compound of Formula (XVI) wherein R, R2, R3, R4, R5, R6, R7 and n are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmac